Dimethyl Sulfoxide
Apexbio Technology LLC Linezolid(Synonyms: Zyvox, Zyvoxid, U-100766, PNU-100766, U-100766E, PNU100766, Linezolide), 10mM (in 1mL DMSO), CAS: 165800-03-3.
Linezolid (CAS 165800-03-3) is a synthetic oxazolidinone antimicrobial compound with broad-spectrum activity primarily against Gram-positive bacteria including multi-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) vancomycin-resistant Enterococcus (VRE) and penicillin-resistant Streptococcus pneumoniae Linezolid inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit thereby preventing formation of the functional 70S initiation complex In cell-free transcription-translation assays using E coli linezolid demonstrates an IC50 of approximately 1 8 mM Due to its pharmacokinetics and high oral bioavailability linezolid is widely utilized in clinical research related to complicated skin infections and bacterial pneumonia
Apexbio Technology LLC A-674563 552325-73-2 10mM (in 1mL DMSO)
A-674563 (CAS 552325-73-2) is a potent inhibitor of the serine/threonine kinase Akt1 (protein kinase B) with an IC50 of 14 nM It also demonstrates inhibitory activity against PKA and CDK2 with IC50 values of 16 nM and 46 nM respectively Akt regulates diverse cellular processes including proliferation apoptosis metabolism transcription and migration In cellular assays A-674563 suppresses proliferation in MiaPaCa-2 cells (EC50 0 4 M) reduces phosphorylation of GSK3 and MDM2 and induces G2-phase cell-cycle arrest and apoptosis in STS cells In mouse xenograft studies this inhibitor delays tumor growth and enhances paclitaxel efficacy illustrating its utility in oncology research
Apexbio Technology LLC Indirubin 479-41-4 10mM (in 1mL DMSO)
Indirubin (CAS 479-41-4) is a small molecule isolated from Danggui Longhui Wan a herbal medicine formulation It exerts anti-inflammatory effects primarily through the inhibition of interferon-gamma (IFN- ) production In vitro studies demonstrated that Indirubin suppresses IFN- secretion in human bone marrow mononuclear cells (HBL-38) and murine splenocytes without affecting cell proliferation In vivo administration of Indirubin reduced ear swelling in a mouse model of 2 4 6-trinitro-1-chlorobenzene (TNCB)-induced delayed-type hypersensitivity concomitant with decreased IFN- levels in lymphocyte cultures Indirubin is under clinical investigation for conditions such as psoriasis and acute promyelocytic leukemia
Apexbio Technology LLC Skepinone-L 1221485-83-1 10mM (in 1mL DMSO)
Skepinone-L (CAS 1221485-83-1) is a selective ATP-competitive inhibitor of p38 mitogen-activated protein kinase (MAPK) This kinase family transduces signals from diverse cellular stressors regulating processes like apoptosis and differentiation Skepinone-L potently inhibits p38 MAPK activity with an IC50 of approximately 5 nM In vitro it dose-dependently reduces phosphorylation of heat shock protein 27 (HSP27) a downstream marker of p38 MAPK in HeLa cells Additionally the compound suppresses key cytokine release (e g TNF- IL-1 IL-10) in human peripheral blood mononuclear cells Oral administration in mice effectively reduced TNF- production illustrating potential applications in inflammation and signaling pathway research
Apexbio Technology LLC Olmesartan 144689-24-7 10mM (in 1mL DMSO)
Olmesartan (CAS 144689-24-7) is a small molecule angiotensin II receptor antagonist primarily acting by selectively blocking the binding of angiotensin II to AT1 receptors This mechanism interrupts angiotensin II-mediated vasoconstriction and aldosterone secretion resulting in antihypertensive effects In biomedical research Olmesartan serves as a valuable tool for examining hypertensive disease models elucidating angiotensin II signaling pathways and exploring therapeutic strategies targeting cardiovascular regulation
Apexbio Technology LLC D4476 301836-43-1 10mM (in 1mL DMSO)
D4476 (CAS 301836-43-1) is a selective cell-permeable inhibitor of casein kinase 1 (CK1) and ALK5 exhibiting IC50 values of 0 3 M for CK1 and 0 5 M for ALK5 (at 0 1 mM ATP in vitro) It likely acts via ATP-competitive inhibition of CK1 showing minimal to no significant inhibitory activity against SAPK2a/p38 PKB or SGK Treatment with D4476 inhibits CK1-mediated phosphorylation of FOXO1a (Ser322 and Ser325) and RhoB (Ser185) in H4IIE and HeLa cells respectively impacting downstream processes such as nuclear export dynamics and actin cytoskeleton regulation Additionally it induces partial p53-dependent growth arrest in HCT116 cells
Apexbio Technology LLC Gliclazide 21187-98-4 10mM (in 1mL DMSO)
Gliclazide (CAS 21187-98-4) is an oral hypoglycemic agent classified structurally as a sulfonylurea derivative It exerts its biological effects primarily by targeting pancreatic beta-cell sulfonylurea receptors (SUR1) stimulating insulin secretion through the closure of ATP-dependent potassium channels This channel inhibition induces cellular depolarization facilitating calcium influx and subsequent insulin exocytosis In a research context gliclazide is utilized extensively as a pharmacological tool to study pancreatic beta-cell function insulin secretion dynamics and diabetic pathophysiology
Apexbio Technology LLC (S)-(+)-Ibuprofen(Synonyms: Dexibuprofen, (S)-Ibuprofen, (S)-(+)-2-(4-Isobutylphenyl)propionic acid), 10mM (in 1mL DMSO), CAS: 51146-56-6.
(S)-( )-Ibuprofen (CAS 51146-56-6) is the pharmacologically active enantiomer of the racemic nonsteroidal anti-inflammatory drug (NSAID) ibuprofen Unlike its R(-)-counterpart the S( )-form selectively inhibits cyclooxygenase (COX) enzymes thereby suppressing prostaglandin synthesis at concentrations relevant to clinical settings Due to this stereoselectivity (S)-( )-ibuprofen is widely utilized in biomedical research investigating pain inflammation pathways COX enzyme activity and related drug-target interactions
Apexbio Technology LLC RG7388 1229705-06-9 10mM (in 1mL DMSO)
RG7388 (CAS 1229705-06-9) is a second-generation selective inhibitor of the MDM2-p53 interaction It functions by blocking the binding between MDM2 and wild-type p53 thereby stabilizing and activating the p53 tumor-suppressor pathway In human cancer cell lines RG7388 shows high potency with reported IC50 values of 6 nM (MDM2 binding assay) and 0 03 M (MTT assay) Preclinical studies demonstrate cell-cycle arrest and apoptosis selectively in wild-type p53-expressing cells and tumor regression in xenograft mouse models including sarcoma and neuroblastoma RG7388 is currently under clinical evaluation for multiple solid and hematologic malignancies
Apexbio Technology LLC Ambrisentan 177036-94-1 10mM (in 1mL DMSO)
Ambrisentan (CAS 177036-94-1) is an orally active selective endothelin receptor antagonist specifically targeting ETA receptors It exhibits strong selectivity towards ETA over ETB receptor subtypes shown by Ki values of approximately 1 nM for recombinant ETA receptors expressed in vitro versus 195 nM for ETB In recombinant human receptor assays using intact cells this selectivity is enhanced with reported Ki values of 0 63 nM (ETA) and 48 7 nM (ETB) Pharmacologically ambrisentan s selective ETA blockade preserves the ETB receptor s intrinsic vasodilatory and endothelin clearance functions making it useful in research involving pulmonary arterial hypertension cerebrovascular conditions and ischemia-reperfusion injury
Apexbio Technology LLC Ulipristal 159811-51-5 10mM (in 1mL DMSO)
Ulipristal is a selective progesterone receptor modulator (SPRM) exhibiting tissue-specific agonist and antagonist activities on progesterone-sensitive targets It functions through competitively binding to the progesterone receptor thereby modulating downstream cellular and physiological responses Ulipristal has been explored in biomedical research primarily for emergency contraception administered within 120 hours following unprotected intercourse Additionally ulipristal demonstrates potential utility in managing benign gynecological disorders such as uterine fibroids (leiomyomas) by mediating apoptosis in myomatous cells and controlling cellular proliferation In vitro studies indicate that ulipristal acetate inhibits progesterone-stimulated acrosome reactions and hyperactivation of human spermatozoa highlighting its potential receptor-mediated modulation of sperm functions
Apexbio Technology LLC GDC-0068 (RG7440) 1001264-89-6 10mM (in 1mL DMSO)
GDC-0068 (RG7440 CAS number 1001264-89-6) is a selective small-molecule inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 It inhibits Akt activity with IC50 values of 5 nM 18 nM and 8 nM for Akt1 Akt2 and Akt3 respectively Akt signaling within the PI3K-Akt pathway regulates cellular proliferation survival and tumorigenesis and is frequently dysregulated in cancers harboring mutations in PTEN or PI3K GDC-0068 binds to and inhibits Akt activation resulting in reduced tumor cell proliferation cell-cycle arrest and induction of apoptosis supporting its utility in oncology research
Apexbio Technology LLC NU7441 (KU-57788) 503468-95-9 10mM (in 1mL DMSO)
NU7441 (KU-57788 CAS 503468-95-9) is a selective inhibitor targeting DNA-dependent protein kinase (DNA-PK) via competition with ATP exhibiting an IC50 of approximately 13 nM and a Ki of 0 65 nM It demonstrates high specificity showing minimal inhibition of related kinases ATM and ATR at concentrations up to 100 M and substantially weaker activity towards mTOR and PI3K (IC50 values of 1 7 and 5 M respectively) NU7441 sensitizes HeLa cells to etoposide enhancing cytotoxicity and augments tumor growth delay when co-administered in SW620 xenograft mouse models The molecule serves as a tool compound in DNA repair and oncology research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Apexbio Technology LLC Alexidine dihydrochloride 1715-30-6 10mM (in 1mL DMSO)
Alexidine dihydrochloride is a selective inhibitor targeting mitochondrial protein tyrosine phosphatase 1 (PTPMT1) exhibiting inhibitory activity with an IC50 value of approximately 1 08 M in vitro By inhibiting PTPMT1 Alexidine dihydrochloride modulates mitochondrial signaling pathways implicated in cellular metabolism Additionally this compound enhances insulin secretion in pancreatic -cells of rat islet models In cancer biology research Alexidine dihydrochloride demonstrates activity against FaDu cells providing a relevant tool for studying mitochondrial phosphatase-mediated mechanisms in oncology and diabetes-related research applications